Levine Lab
Dr. Brian Levine is a neuropsychologist interested in the function and dysfunction of large-scale neural systems as expressed in complex human behaviors, including episodic and autobiographical memory, self-regulation, and goal management. Much of his research concerns syndromes seen in patients with focal brain lesions due to strokes and tumors, traumatic brain injury, dementia, and psychiatric disorders, although he also studies healthy young and older adults. Dr. Levine is particularly interested in the real-life deficits faced by patients with brain disease. As these deficits are often not readily apparent in standard neuropsychological or neurological examinations, Dr. Levine uses novel assessment techniques, coupled with multimodal neuroimaging (structural and functional MRI, EEG, and MEG) in his research.
Recent Publications
Raja Beharelle, A., Kovacevic, N., McIntosh, A.R., Levine, B. (in press). Brain signal variability relates to stability of behavior after recovery from diffuse brain injury. Neuroimage.
Raja Beharelle, A., Tisserand, D., McIntosh, A.R., Levine, B. (2011) Brain activity patterns uniquely supporting visual feature integration after traumatic brain injury. Frontiers in Neuroscience, 5, 164. DOI: 10.3389/fnhum.2011.00164.
Mind and the frontal lobes: cognition, behavior, and brain imaging. Levine, B. & Craik, F.I.M., New York: Oxford University Press (2012).
Levine, B., Schweizer, T. A., O’Connor, C., Turner, G. R., Gillingham, S., Stuss, D. T., Manly, T., & Robertson, I.H. (2011). Rehabilitation of executive functioning in patients with frontal lobe brain damage with Goal Management Training. Frontiers in Human Neuroscience, 5:9. doi: 10.3389/fnhum.2011.00009.
Turner, G.R., McIntosh, A.R., & Levine, B. (2011). Compensatory neural recruitment during verbal working memory performance after TBI: evidence for an altered functional engagement hypothesis. Frontiers in Systems Neuroscience, 5:9. doi: 10.3389/fnsys.2011.00009.
O’Connor, C., Robertson, I.H., & Levine, B. (2011). Neural correlates of endogenous vs. exogenous engagement during performance of a sustained attention task. Neuropsychology.
Söderlund, H., Moscovitch, M., Kumar, N., Mandic, M., & Levine, B. (2011). As time goes by: Hippocampal connectivity changes with remoteness of autobiographical memory retrieval. Hippocampus.
Spreng, R.N., Rosen, H.J., Black, S.E., Chow, T.W., Diehl-Schmid, J., Freedman, M., Graff-Radford, N.R., Hodges, J.R., Lipton, A.M., Mendez, M.F., Morelli, S.A., Miller, B.L., & Levine, B. (2010). Occupation attributes relate to laterality of atrophy in frontotemporal lobar degeneration. Neuropsychologia, 48, 3634-3641.
Levine, B., Svoboda, E.M., Turner, G.R., Mandic, M., & Mackey, A. (2009). Behavioral and functional neuroanatomical correlates of autobiographical memory in isolated retrograde amnesic patient M.L. Neuropsychologia, 47, 2188-2196.
Svoboda E & Levine B. (2009). The effects of rehearsal on the functional neuroanatomy of episodic autobiographical and semantic remembering: a functional magnetic resonance imaging study. Journal of Neuroscience, 29, 3073-3082.
McKinnon, M. C., Nica, E. I., Sengdy, P., Kovacevic, N., Moscovitch, M., Freedman, M., Miller, B. L., Black, S. E., & Levine, B. (2008) Autobiographical memory and patterns of brain atrophy in frontotemporal lobar degeneration. Journal of Cognitive Neuroscience, 20, 1839-1853.
Turner, G.R. and Levine, B. (2008). Augmented neural activity during executive control processing following diffuse axonal injury. Neurology, 71, 812-18.
Levine, B., Kovacevic, N., Nica, E.I., Gao, F., Schwartz, M.L., & Black, S.E. The Toronto TBI study: injury severity and quantified MRI. (2008). Neurology, 70, 771-778.